{"id":2369,"date":"2024-10-29T15:59:27","date_gmt":"2024-10-29T14:59:27","guid":{"rendered":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/?page_id=2369"},"modified":"2025-02-06T00:47:55","modified_gmt":"2025-02-05T23:47:55","slug":"projet-nanobioid","status":"publish","type":"page","link":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/projet-nanobioid\/","title":{"rendered":"projet NanobioID"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2369\" class=\"elementor elementor-2369\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6786c7b e-grid e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"6786c7b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d2eaafd elementor-widget elementor-widget-text-editor\" data-id=\"d2eaafd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 26-05-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Le projet NanoBioID<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-80984a5 e-grid e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"80984a5\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8388af5 elementor-widget elementor-widget-text-editor\" data-id=\"8388af5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>D\u00e9marr\u00e9 en\u00a0novembre 2022, le projet NanoBioID (<strong><u>ANR 2022-2026, leader Dr S. Mornet, <\/u><\/strong><strong><u>138<\/u><\/strong><strong><u>k<\/u><\/strong><strong><u>\u20ac pour le CRMSB)<\/u><\/strong> propose un <strong>th\u00e9ranostic des plaques d\u2019ath\u00e9rome, bas\u00e9 sur des nanoparticules magn\u00e9tiques (NPM)<\/strong> <strong>biomim\u00e9tiques et biocompatibles<\/strong>.<\/p><p>Dans ce projet, le Dr S. Mornet (<strong>ICMCB<\/strong>, Bordeaux) propose de d\u00e9velopper des NPM dont la chimie de surface vise \u00e0 augmenter le temps de circulation et l\u2019adressage aux plaques. Le but est d\u2019obtenir une couronne prot\u00e9ique au profil st\u0153chiom\u00e9trique opsonine\/dysopsonine favorable \u00e0 une distribution optimis\u00e9e notamment via l\u2019adsorption d\u2019ApoA1 pour un ciblage efficace des plaques d\u2019ath\u00e9rome. Il est clairement \u00e9tabli que la corona form\u00e9e par des interactions avec des prot\u00e9ines plasmatiques sur les NPM inject\u00e9es d\u00e9termine leur identit\u00e9 biologique, dictant leurs propri\u00e9t\u00e9s de capture cellulaire et leur devenir\u00a0<em>in vivo<\/em>.<\/p><p><span style=\"color: #0000ff;\">L<u>e projet NanoBioID\u00a0est organis\u00e9 autour de 3 autres partenaires\u00a0<\/u>:<\/span>\u00a0Le Dr Ariane Boudier (<strong>CITHEFOR<\/strong>, universit\u00e9 de Lorraine) \u00e9tudie les interactions physicochimiques des NPM avec les prot\u00e9ines. Le Dr Anne-Aur\u00e9lie Raymond (<strong>ONCOPROT<\/strong>, Bordeaux) r\u00e9alise un profiling prot\u00e9omique sur les diff\u00e9rentes NPM de fa\u00e7on \u00e0 r\u00e9v\u00e9ler leur identit\u00e9 biologique. Notre r\u00f4le au <strong>CRMSB<\/strong> consiste \u00e0 tester diff\u00e9rentes formulations de NPM (enrichies en ApoA1) pour leur capacit\u00e9 \u00e0 se lier aux MP spumeux (impact pour le diagnostic) mais aussi \u00e0 induire un effet th\u00e9rapeutique (efflux du cholest\u00e9rol et immunor\u00e9gulation li\u00e9e \u00e0 l\u2019action de l\u2019ApoA1)<em>.<\/em> Ensuite, pour le mod\u00e8le murin Apoe<sup>-\/-<\/sup>, ces NMP seront d\u00e9velopp\u00e9es sous un format bimodal permettant un suivi par tomographie de fluorescence dans le proche infrarouge et par IRM.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8f944f9 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"8f944f9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-325eedb elementor-widget elementor-widget-image\" data-id=\"325eedb\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 26-05-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"768\" height=\"540\" src=\"https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2024\/10\/Image-figure-nanobioID-768x540.png\" class=\"attachment-medium_large size-medium_large wp-image-2371\" alt=\"\" srcset=\"https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2024\/10\/Image-figure-nanobioID-768x540.png 768w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2024\/10\/Image-figure-nanobioID-300x211.png 300w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2024\/10\/Image-figure-nanobioID-1024x719.png 1024w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2024\/10\/Image-figure-nanobioID.png 1331w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d585c7c e-grid e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"d585c7c\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-67f8599 elementor-widget elementor-widget-text-editor\" data-id=\"67f8599\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><em><span style=\"color: #3366ff;\">Cliquer sur les icones ci-dessous pour naviguer dans cet axe:<\/span><\/em><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-446b3a8 e-grid e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"446b3a8\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4c6eb10 elementor-widget elementor-widget-image\" data-id=\"4c6eb10\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/la-recherche\/equipe-metapat\/switches-metabolique-et-fonctionnel\/\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"300\" height=\"103\" src=\"https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/axe-300x103.png\" class=\"attachment-medium size-medium wp-image-3128\" alt=\"\" srcset=\"https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/axe-300x103.png 300w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/axe-768x265.png 768w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/axe.png 891w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b526066 elementor-widget elementor-widget-image\" data-id=\"b526066\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/macrophage-et-atherosclerose\/\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"300\" height=\"103\" src=\"https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/Macrophage-1-300x103.png\" class=\"attachment-medium size-medium wp-image-3123\" alt=\"\" srcset=\"https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/Macrophage-1-300x103.png 300w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/Macrophage-1-768x265.png 768w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/Macrophage-1.png 891w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bacbe27 e-grid e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"bacbe27\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-70a47af elementor-widget elementor-widget-image\" data-id=\"70a47af\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/projet-abcardionostics\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"114\" src=\"https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/projet-I-1-300x114.png\" class=\"attachment-medium size-medium wp-image-3131\" alt=\"\" srcset=\"https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/projet-I-1-300x114.png 300w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/projet-I-1-768x291.png 768w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/projet-I-1.png 811w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4772a65 elementor-widget elementor-widget-image\" data-id=\"4772a65\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/projet-meap\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"114\" src=\"https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/projet-II-300x114.png\" class=\"attachment-medium size-medium wp-image-3130\" alt=\"\" srcset=\"https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/projet-II-300x114.png 300w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/projet-II-768x291.png 768w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/projet-II.png 811w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-862d916 elementor-widget elementor-widget-image\" data-id=\"862d916\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/projet-lpcbiomab\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"111\" src=\"https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/Porjet-III-300x111.png\" class=\"attachment-medium size-medium wp-image-3138\" alt=\"\" srcset=\"https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/Porjet-III-300x111.png 300w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/Porjet-III-768x283.png 768w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/Porjet-III.png 810w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Le projet NanoBioID D\u00e9marr\u00e9 en\u00a0novembre 2022, le projet NanoBioID (ANR 2022-2026, leader Dr S. Mornet, 138k\u20ac pour le CRMSB) propose un th\u00e9ranostic des plaques d\u2019ath\u00e9rome, bas\u00e9 sur des nanoparticules magn\u00e9tiques (NPM) biomim\u00e9tiques et biocompatibles. Dans ce projet, le Dr S. Mornet (ICMCB, Bordeaux) propose de d\u00e9velopper des NPM dont la chimie de surface vise \u00e0 augmenter le temps de circulation et l\u2019adressage aux plaques. Le but est d\u2019obtenir une couronne prot\u00e9ique au profil st\u0153chiom\u00e9trique opsonine\/dysopsonine favorable \u00e0 une distribution optimis\u00e9e notamment via l\u2019adsorption d\u2019ApoA1 pour un ciblage efficace des plaques d\u2019ath\u00e9rome. Il est clairement \u00e9tabli que la corona form\u00e9e par des interactions avec des prot\u00e9ines plasmatiques sur les NPM inject\u00e9es d\u00e9termine leur identit\u00e9 biologique, dictant leurs propri\u00e9t\u00e9s de capture cellulaire et leur devenir\u00a0in vivo. Le projet NanoBioID\u00a0est organis\u00e9 autour de 3 autres partenaires\u00a0:\u00a0Le Dr Ariane Boudier (CITHEFOR, universit\u00e9 de Lorraine) \u00e9tudie les interactions physicochimiques des NPM avec les prot\u00e9ines. Le Dr Anne-Aur\u00e9lie Raymond (ONCOPROT, Bordeaux) r\u00e9alise un profiling prot\u00e9omique sur les diff\u00e9rentes NPM de fa\u00e7on \u00e0 r\u00e9v\u00e9ler leur identit\u00e9 biologique. Notre r\u00f4le au CRMSB consiste \u00e0 tester diff\u00e9rentes formulations de NPM (enrichies en ApoA1) pour leur capacit\u00e9 \u00e0 se lier aux MP spumeux (impact pour le diagnostic) mais aussi \u00e0 induire un effet th\u00e9rapeutique (efflux du cholest\u00e9rol et immunor\u00e9gulation li\u00e9e \u00e0 l\u2019action de l\u2019ApoA1). Ensuite, pour le mod\u00e8le murin Apoe-\/-, ces NMP seront d\u00e9velopp\u00e9es sous un format bimodal permettant un suivi par tomographie de fluorescence dans le proche infrarouge et par IRM. Cliquer sur les icones ci-dessous pour naviguer dans cet axe:<\/p>\n","protected":false},"author":14,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/pages\/2369"}],"collection":[{"href":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/comments?post=2369"}],"version-history":[{"count":65,"href":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/pages\/2369\/revisions"}],"predecessor-version":[{"id":3292,"href":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/pages\/2369\/revisions\/3292"}],"wp:attachment":[{"href":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/media?parent=2369"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}