{"id":930,"date":"2023-12-18T12:17:48","date_gmt":"2023-12-18T12:17:48","guid":{"rendered":"http:\/\/192.168.10.216\/?page_id=930"},"modified":"2025-02-06T00:37:12","modified_gmt":"2025-02-05T23:37:12","slug":"switches-metabolique-et-fonctionnel","status":"publish","type":"page","link":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/la-recherche\/equipe-metapat\/switches-metabolique-et-fonctionnel\/","title":{"rendered":"Switches m\u00e9tabolique et fonctionnel"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"930\" class=\"elementor elementor-930\">\n\t\t\t\t<div class=\"elementor-element elementor-element-16ec096 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"16ec096\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0904390 elementor-widget elementor-widget-heading\" data-id=\"0904390\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 26-05-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">Switches m\u00e9tabolique et fonctionnel<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e88db5e e-grid e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"e88db5e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7244776 elementor-widget elementor-widget-heading\" data-id=\"7244776\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Axe dirig\u00e9 par le Dr Florence OTTONES <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-925bf3c e-grid e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"925bf3c\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-a1cb531 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-child\" data-id=\"a1cb531\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b4fd5cf elementor-widget elementor-widget-image\" data-id=\"b4fd5cf\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 26-05-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"489\" src=\"https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2024\/10\/logo-axe-2-1024x489.png\" class=\"attachment-large size-large wp-image-2244\" alt=\"\" srcset=\"https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2024\/10\/logo-axe-2-1024x489.png 1024w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2024\/10\/logo-axe-2-300x143.png 300w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2024\/10\/logo-axe-2-768x367.png 768w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2024\/10\/logo-axe-2-1536x733.png 1536w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2024\/10\/logo-axe-2.png 1844w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0b40792 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"0b40792\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ee3a2b2 elementor-widget elementor-widget-text-editor\" data-id=\"ee3a2b2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 26-05-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Les monocytes, macrophages et microglies forment une population extr\u00eamement complexe. Ils peuvent rapidement changer de ph\u00e9notype et de fonction en r\u00e9ponse \u00e0 leur microenvironnement, ce qui en fait une cible id\u00e9ale pour le diagnostic et la th\u00e9rapie de nombreuses pathologies. Dans cet axe, nous exploitons la plasticit\u00e9 de cette population cellulaire dans le contexte de deux pathologies : l\u2019ath\u00e9roscl\u00e9rose (recherches men\u00e9es par le Dr Florence OTTONES) et l\u2019Hypoxie-Isch\u00e9mie N\u00e9onatale (recherches men\u00e9es par le Dr Jeanny LAROCHE-TRAINEAU).<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6febb89 e-grid e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"6febb89\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-189cbd4 elementor-widget elementor-widget-text-editor\" data-id=\"189cbd4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Cliquer sur les icones ci-dessous pour naviguer dans cet axe :<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0cf8b41 e-grid e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"0cf8b41\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ec3d9f0 elementor-widget elementor-widget-image\" data-id=\"ec3d9f0\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/macrophage-et-atherosclerose\/\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"891\" height=\"307\" src=\"https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/Macrophage-1.png\" class=\"attachment-large size-large wp-image-3123\" alt=\"\" srcset=\"https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/Macrophage-1.png 891w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/Macrophage-1-300x103.png 300w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/Macrophage-1-768x265.png 768w\" sizes=\"(max-width: 891px) 100vw, 891px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2b766f4 elementor-widget elementor-widget-image\" data-id=\"2b766f4\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/microglies-ey-hin\/\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"891\" height=\"306\" src=\"https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/Microglie.png\" class=\"attachment-large size-large wp-image-3124\" alt=\"\" srcset=\"https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/Microglie.png 891w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/Microglie-300x103.png 300w, https:\/\/www.rmsb.u-bordeaux.fr\/wp-content\/uploads\/2025\/02\/Microglie-768x264.png 768w\" sizes=\"(max-width: 891px) 100vw, 891px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Switches m\u00e9tabolique et fonctionnel Axe dirig\u00e9 par le Dr Florence OTTONES Les monocytes, macrophages et microglies forment une population extr\u00eamement complexe. Ils peuvent rapidement changer de ph\u00e9notype et de fonction en r\u00e9ponse \u00e0 leur microenvironnement, ce qui en fait une cible id\u00e9ale pour le diagnostic et la th\u00e9rapie de nombreuses pathologies. Dans cet axe, nous exploitons la plasticit\u00e9 de cette population cellulaire dans le contexte de deux pathologies : l\u2019ath\u00e9roscl\u00e9rose (recherches men\u00e9es par le Dr Florence OTTONES) et l\u2019Hypoxie-Isch\u00e9mie N\u00e9onatale (recherches men\u00e9es par le Dr Jeanny LAROCHE-TRAINEAU). Cliquer sur les icones ci-dessous pour naviguer dans cet axe :<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":513,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"right-sidebar","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"_links":{"self":[{"href":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/pages\/930"}],"collection":[{"href":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/comments?post=930"}],"version-history":[{"count":89,"href":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/pages\/930\/revisions"}],"predecessor-version":[{"id":3263,"href":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/pages\/930\/revisions\/3263"}],"up":[{"embeddable":true,"href":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/pages\/513"}],"wp:attachment":[{"href":"https:\/\/www.rmsb.u-bordeaux.fr\/fr\/wp-json\/wp\/v2\/media?parent=930"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}